Hirschsprung disease (HSCR) is a complex congenital disorder caused by defects in the development of the enteric nervous system (ENS). It is attributed to failures of the enteric neural crest stem cells (ENCCs) to proliferate. differentiate and/or migrate. leading to the absence of enteric neurons in the distal colon. https://fitnessgravesyardes.shop/product-category/middle-shroud/