We report a case of methotrexate (MTX)-induced stroke-like encephalopathy in an 18-year-old woman. with acute lymphoblastic leukemia. who developed a sudden neurological deficit mimicking a cerebrovascular event. Bain MRI showed hyperintensities on diffusion-weighted-imaging (DWI) with matching apparent diffusion coefficient hypointensities. https://www.lolasalinas.com/