Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained. Herein. we report the efficient application of this approach to the synthesis of acylhydrazines bearing 1. https://www.roneverhart.com/HP-15-fc0093dx-15-6-FHD-Laptop-AMD-Ryzen-5-7520U-2-8-GHz-AMD-Radeon-16GB-LPDDR5-256GB-SSD-Windows-11-Home-S-8F1A6UA/